Table 7 Nanogel based anti-GBM drug delivery system
Drug | Composite | Modification | Detail | Result |
|---|---|---|---|---|
Teriflunomide (TFM) [188] | TFM@ Gellan gum@ Carbopol 974P | Gellan gum and carbopol 974P were applied as gelling and mucoadhesive agents | Ex vivo nasal permeation was performed by using vertical Franz diffusion cell Cellular uptake, bio-distribution and proliferation were evaluated in U87MG cells Systematic toxicity and bio-distribution were determined in Swiss albino mice model | Enhanced nasal permeation and brain accumulation through i.n. delivery High cytotoxicity potential against tumor cells No hepatotoxicity, nephrotoxicity and hematological toxicity |
Doxorubicin [189] | DOX@Lf@PBA@HA | Lactoferrin was coated onto the nanogels to achive blood brain barrier penetration Hyaluronic acid and phenylboronic acid provided dual targeting for tumor | Cellular uptake and disposition were determined through flow cytometry and CLMS B.End3/G422 coculture model was used to study the transport ability SD rats and ICR mice were utilized to investigate anti-tumor efficacy and bio-distribution respectively | Triggered drug release manner by high GSH Increased cellular uptake through clathrin and caveolin-mediated endocytosis Optimized bio-distribution and higher permeation ability |
TSPO ligand [190] | TSPO ligand-DEX@NG | Cholesterol and porphyrins are known as endogenous ligands for Translocator protein | MTT assay and fluorescence microscopy were utilized in C6 cells Swelling study and rheological study were used to analyze the viscoelastic properties | Proven cellular uptake and cytotoxicity in vivo Excellent stability and controlled release of NG system |
TMZ&PTX [191] | TMZ@PTX@PEG-DMA | Intratumoral implantation was used instead modifications on NG | Clonogenic assay was conducted Orthotopic U87MG human GBM tumor resection nude mice model was estabilished | Synergistic effect of PTX and TMZ on U87MG cells Perisurgical drug delivery in the resection cavity |
Cisplatin [192] | CPT@Cx43 mAb@BSAT1 mAb@NG | The preferential expression of membrane protein connexin 43 (Cx43) and brain-specific anion transporter (BSAT1) in the tumor was employed for targeted drug delivery | MTS assay was used to evaluate in vitro cytotoxicity on C6 cells Intracranial inoculation of rat glioma 101/8 was constructed Tumor volume was determined by MRI scanning | Higher passive penetration across endothelial barrier Increased drug delivery efficacy and internalization in tumor site Prolonged survival time for animal model |