Figure 7
From: Assessment of the In Vivo Toxicity of Gold Nanoparticles
The lethality and immunogenicity of surface-modified 17 nm GNPs. Average lifespans of mice injected with modified 17 nm GNPs are shown in empty columns. Each experimental group received GNP conjugated with BSA, lysozyme, pFMDV, or pH5N1. Unmodified GNPs served as a positive control (17 nm GNP). Titers of antiserum withdrawn from GNP-injected mice against corresponding antigens are shown in filled columns. pH5N1- and pFMDV-coated GNPs induced the highest titer in mouse serum; BSA- and lysozyme-coated GNPs induced a moderate titer; and unmodified GNPs did not induce an antibody response in mice (*)