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Table 1 Advantages and disadvantages of liposome [[19]]

From: Liposome: classification, preparation, and applications

Advantages of liposome Disadvantages of liposome
Liposomes increased efficacy and therapeutic index of drug (actinomycin-D) Low solubility
Liposome increased stability via encapsulation Short half-life
Liposomes are non-toxic, flexible, biocompatible, completely biodegradable, and non-immunogenic for systemic and non-systemic administrations Sometimes phospholipid undergoes oxidation and hydrolysis-like reaction
Liposomes reduce the toxicity of the encapsulated agent (amphotericin B, Taxol) Leakage and fusion of encapsulated drug/molecules
Liposomes help reduce the exposure of sensitive tissues to toxic drugs Production cost is high
Site avoidance effect Fewer stables
Flexibility to couple with site-specific ligands to achieve active targeting