Table 1 Advantages and disadvantages of liposome [[19]]
From: Liposome: classification, preparation, and applications
Advantages of liposome | Disadvantages of liposome |
|---|---|
Liposomes increased efficacy and therapeutic index of drug (actinomycin-D) | Low solubility |
Liposome increased stability via encapsulation | Short half-life |
Liposomes are non-toxic, flexible, biocompatible, completely biodegradable, and non-immunogenic for systemic and non-systemic administrations | Sometimes phospholipid undergoes oxidation and hydrolysis-like reaction |
Liposomes reduce the toxicity of the encapsulated agent (amphotericin B, Taxol) | Leakage and fusion of encapsulated drug/molecules |
Liposomes help reduce the exposure of sensitive tissues to toxic drugs | Production cost is high |
Site avoidance effect | Fewer stables |
Flexibility to couple with site-specific ligands to achieve active targeting |