Table 6 Medullary micronucleus results of mice exposed to C-dots
From: Systematic safety evaluation on photoluminescent carbon dots
Gender | Dose | No. | PCE | Micronucleus PCE | Micronucleus cell rate ( ‰) | P value | PCE/NCE | |
|---|---|---|---|---|---|---|---|---|
No. | ± S | |||||||
Female | Negative control | 5 | 5 × 1,000 | 5 | 1.0 ± 0.7 | 1.0 | 1.33 ± 0.18 | |
Low | 5 | 5 × 1,000 | 4 | 0.8 ± 0.8 | 0.8 | 1.33 ± 0.31 | ||
Middle | 5 | 5 × 1,000 | 4 | 0.8 ± 0.4 | 0.8 | 1.33 ± 0.19 | ||
High | 5 | 5 × 1,000 | 5 | 1.0 ± 0.7 | 1.0 | 1.28 ± 0.19 | ||
Positive control | 5 | 5 × 1,000 | 157 | 31.4 ± 5.8*** | 31.4 | 0.000 | 1.23 ± 0.08 | |
Male | Negative control | 5 | 5 × 1,000 | 2 | 0.4 ± 0.5 | 0.4 | 1.41 ± 0.12 | |
Low | 5 | 5 × 1,000 | 3 | 0.6 ± 0.5 | 0.6 | 1.40 ± 0.08 | ||
Middle | 5 | 5 × 1,000 | 2 | 0.4 ± 0.5 | 0.4 | 1.36 ± 0.11 | ||
High | 5 | 5 × 1,000 | 3 | 0.6 ± 0.5 | 0.6 | 1.41 ± 0.10 | ||
Positive control | 5 | 5 × 1,000 | 163 | 32.6 ± 6.4*** | 32.6 | 0.000 | 1.22 ± 0.07 | |