Studies of single-walled carbon nanotubes-induced hepatotoxicity by NMR-based metabonomics of rat blood plasma and liver extracts

Table 2 Summary of rat plasma metabolite variations induced by SWCNTs administration

Chemical shift (δ, ppm)	Metabolites	SWCNTs-L group	SWCNTs-M group	SWCNTs-H group
0.80-0.90, 1.20-1.29	Lipoprotein	↓	↓	↑
0.94	Ile + Leu	↑	↑	↑
1.31-1.33, 4.10-4.12	Lactate	↑	↑	↑
1.48	Alanine	↓	↓	↓
1.91	Acetate	↓	↓	↑
2.03-2.04	NAc	↑	↑	↑
2.13-2.14	OAc	↑	↑	↑
2.42-2.44	Gln-glutamine	↑	↑	↑
3.03	Creatine	↓	↓	↑
3.20	Cho	↑	↑	↑
3.22, 3.23	PCho	↑	↑	↑
3.40-4.00	Glucose	↓	↓	↓
0.70	HDL	↑	↓	↑
0.82, 0.86	VLDL/LDL	↓	↓	↓
1.10	HDL	↑	↓	↑
1.26	VLDL/LDL	↓	↓	↓
1.58	Lipid CH₂CH₂CO	↓	↑	↓
2.02	NAc	↑	↓	↑
2.14	OAc	↓	↑	↑
2.26	Lipid CH₂CO	↓	↑	↓
3.22	PtdCho	↓	↑	↓
5.30	UFA	↑	↓	↑

Ile, isoleucine; Leu, leucine; NAc, n-acetylgalactosamine; OAc, O-acetyl glucoprotein; Cho, choline; PCho, phosphatidylcholine; HDL, high-density lipoprotein; VLDL, very low density lipoprotein; LDL, low-density lipoprotein; PtdCho, phosphatidylcholine; UFA, unesterified fatty acids. Down arrow indicates decrease, and up arrow indicates increase, compared to control.