Studies of single-walled carbon nanotubes-induced hepatotoxicity by NMR-based metabonomics of rat blood plasma and liver extracts

Table 4 Summary of metabolite variations induced by SWCNTs in lipid-soluble rat liver tissue extract

Chemical shift (δ, ppm)	Metabolites	SWCNTs-L group	SWCNTs-M group	SWCNTs-H group
0.66	Total cholesterol	↑	↓	↓
0.89	Total cholesterol + PUFA (CH₃)	↓	↑	↓
1.05-1.18	Cholesterol	↑	↓	↓
1.26	Lipids (-CH₂-CH₂-CH₂-)	↓	↓	↓
1.51	Cholesterol	↑	↑	↑
1.58	Lipids (CH₂CH₂CO)	↓/-	↑/-	↓/-
1.82	Cholesterol	↑	↑	↑
2.00	PUFA (CH=CH-CH₂-CH=CH) FA (CH=CH-CH₂-CH=CH)	↓	↓/-	↓
2.76	PUFA (=CH-CH₂-CH-)	↓	↑	↓
3.30	Phosphatidylcholine (Me³N^+-)	↓	↓	↑
4.27	Glycerol in PC/PE/TG	↑	-	↑

PUFA, polyunsaturated fatty acid; FA, fatty acid. Down arrow indicates decrease; up arrow indicates increase; and a hyphen means no change, compared to control.