Table 1 Preparation and physico-chemical characteristics of PS-QD micelles
Polar lipids (mg) | PS (mg) | QD (620 nm; 2-μM concentration) | Clarity of emulsion | Stability of flourescence | Average size (by intensity; in nm) | Polydispersity index (PDI) | Zeta potential charge (in mV) | |
|---|---|---|---|---|---|---|---|---|
QD-PEG-PS mole ratio | DSPE-PEG (2000) methoxy | |||||||
100:0, PS (0) | 4.5 | - | 0.2 nmol | Clear | Quenched after 45 days | 198.3 | 0.24 | -8.7 |
60:40, PS (40) | 2.7 | 1.8 | 0.2 nmol | Clear | Stable | 104.6 | 0.18 | -16.4 |
50:50, PS (50) | 2.25 | 2.25 | 0.2 nmol | Clear | Stable | 40.9 | 0.14 | -14.5 |
40:60, PS (60) | 1.8 | 2.7 | 0.2 nmol | Hazy | Stable | 143.0 | 0.16 | -21.8 |
0:100, PS (100) | - | 4.5 | 0.2 nmol | Hazy | Stable | 127.3 | 0.22 | -32.2 |
QD-PEG-COOH | DSPE-PEG (2000) carboxylic acid | |||||||
4.5 | - | 0.2 nmol | Clear | Stable | 60.1 | 0.22 | -25.3 |