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Nanoscale Research Letters
Figure 10 | Nanoscale Research Letters

Figure 10

From: Oxidative stress mediated cytotoxicity of biologically synthesized silver nanoparticles in human lung epithelial adenocarcinoma cell line

Figure 10

Intracellular localization of AgNPs and accumulation of autophagosomes and autolysosomes. A549 cells were treated with silver nanoparticles (AgNPs) for 24 h and then processed for transmission electron microscopy (TEM) sections. TEM images of ultramicrotome slices of A549 cells without AgNPs (A), internalization of biologically synthesized AgNPs (bio-AgNPs) (B), and internalization of chemically synthesized AgNPs (chem-AgNPs) within the cells (C). Bio-AgNPs induces accumulation of autophagosomes (black arrow) and autolysosomes (white arrow) in cells treated with bio-AgNPs for 24 h (D). Autolysosomes and vesicular structures consistent with autophagy were detected in cells treated with bio-AgNPs (E) and chem-AgNPs (F).

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