Figure 6

Tumor mass of HCT116 tumor xenograft-induced nude mice. Ten days after tumor implantation, drug solution was injected intravenously (Paclitaxel dose 10 mg/kg). Control - PBS (0.1 M, pH 7.4); Paclitaxel + Empty nanoparticle treatment - paclitaxel dissolved in Cremophor EL/ethanol mixture (5/5, v/v) was diluted ten times with PBS and mixed with aqueous solution of empty nanoparticles (the content of empty nanoparticles in this treatment were adjusted to similar concentration with paclitaxel NP treatment; paclitaxel-incorporated nanoparticles (Paclitaxel NP) - aqueous solution of paclitaxel-incorporated nanoparticles (PHO/PEG 5 K) was sterilized with a 0.8-μm syringe filter.