Figure 7

Growth inhibitory effects of FA-DM1-NPs and S-DM1 on MCF-7/HER2 cells in vivo . SCID mice with tumor cell xenografts were treated with PBS, FA-NPs (6 μg/g, i.v., n =10), FA-DM1-NPs (10 μg/g equivalent DM1 5 μg/g, i.v., n =10), or S-DM1 (5.2 μg/g equivalent DM1 5 μg/g, i.v., n =10). Drug administration was conducted on days 10, 13, and 16, respectively. FA-NPs had no effect on tumor growth. Tumor shrinkage was seen by DM1 from day 38. From day 34 onwards, all of the FA-DM1-NP-treated tumors were unmeasurable.