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Figure 7 | Nanoscale Research Letters

Figure 7

From: Enhanced anticancer activity of DM1-loaded star-shaped folate-core PLA-TPGS nanoparticles

Figure 7

Growth inhibitory effects of FA-DM1-NPs and S-DM1 on MCF-7/HER2 cells in vivo . SCID mice with tumor cell xenografts were treated with PBS, FA-NPs (6 μg/g, i.v., n =10), FA-DM1-NPs (10 μg/g equivalent DM1 5 μg/g, i.v., n =10), or S-DM1 (5.2 μg/g equivalent DM1 5 μg/g, i.v., n =10). Drug administration was conducted on days 10, 13, and 16, respectively. FA-NPs had no effect on tumor growth. Tumor shrinkage was seen by DM1 from day 38. From day 34 onwards, all of the FA-DM1-NP-treated tumors were unmeasurable.

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