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Table 5 Changes in biochemical parameters from serum of orally treated rats with nanocomposite

From: Acute oral toxicity and biodistribution study of zinc-aluminium-levodopa nanocomposite

Group ALT U / L ALP U / L AST U / L CK U / L ALT / AST ratio Creat μmol / L GGT Urea Mmol / L Na Mmol / L K Mmol / L Cl Mmol / L
ZAL 66 ± 17 256 ± 18 152 ± 30 3,889 ± 71 0.43 ± 0.03 48 ± 1 <3 7 ± 1 142 ± 4 9 ± 1 102 ± 3
ZA 61 ± 6 293 ± 38 111 ± 18 3,398 ± 187 0.55 ± 0.06 47 ± 8 <3 6 ± 1 145 ± 12 8 ± 1 103 ± 10
VC 59 ± 8 312 ± 40 114 ± 11 4,410 ± 364 0.51 ± 0.02 46 ± 4 <3 6 143 ± 2 8 ± 1 101 ± 1
  1. All data are expressed as means ± SD, and groups were compared using one-way ANOVA (n = 5) for any statistical difference between and within groups. Differences with P < 0.05 are considered statistically significant, but none of the parameters measured were found to be significantly different compared to the control group (P > 0.05). ALT, alanine aminotransferase; AST, aspartate aminotransferase; CK, creatine kinase; Creat, creatinine; GGT, gamma-glutamyltransferase; Na, sodium; K, potassium; Cl, chloride.
  2. Microscopic appearance of liver stained with H&E.