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Table 5 Changes in biochemical parameters from serum of orally treated rats with nanocomposite

From: Acute oral toxicity and biodistribution study of zinc-aluminium-levodopa nanocomposite

Group

ALT U / L

ALP U / L

AST U / L

CK U / L

ALT / AST ratio

Creat μmol / L

GGT

Urea Mmol / L

Na Mmol / L

K Mmol / L

Cl Mmol / L

ZAL

66 ± 17

256 ± 18

152 ± 30

3,889 ± 71

0.43 ± 0.03

48 ± 1

<3

7 ± 1

142 ± 4

9 ± 1

102 ± 3

ZA

61 ± 6

293 ± 38

111 ± 18

3,398 ± 187

0.55 ± 0.06

47 ± 8

<3

6 ± 1

145 ± 12

8 ± 1

103 ± 10

VC

59 ± 8

312 ± 40

114 ± 11

4,410 ± 364

0.51 ± 0.02

46 ± 4

<3

6

143 ± 2

8 ± 1

101 ± 1

  1. All data are expressed as means ± SD, and groups were compared using one-way ANOVA (n = 5) for any statistical difference between and within groups. Differences with P < 0.05 are considered statistically significant, but none of the parameters measured were found to be significantly different compared to the control group (P > 0.05). ALT, alanine aminotransferase; AST, aspartate aminotransferase; CK, creatine kinase; Creat, creatinine; GGT, gamma-glutamyltransferase; Na, sodium; K, potassium; Cl, chloride.
  2. Microscopic appearance of liver stained with H&E.

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