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Table 4 The ratio of survived mice and CFU in different organs of infected mice

From: Enhanced Antifungal Activity by Ab-Modified Amphotericin B-Loaded Nanoparticles Using a pH-Responsive Block Copolymer

  Log CFU gram tissue (n = 3) Survival ratioa (%, n = 20)
Lung Spleen Kidney Liver
Control (untreated) 4.35 ± 0.27 3.08 ± 0.25 4.78 ± 0.33 3.41 ± 0.34 0.0
PBS 4.29 ± 0.35 3.14 ± 0.21 4.75 ± 0.29 3.34 ± 0.33 0.0
Free AMB 2.51 ± 0.11* 1.12 ± 0.09* 1.21 ± 0.26* 1.87 ± 0.25* 55.0
CDA-AMB-NPs 1.01 ± 0.06*# Nil** Nil** Nil** 95.0
  1. Values are expressed as mean ± SEM from four separate experiments. t test values (two-tailed) are significant
  2. *p < 0.05, **p < 0.01 vs control; #p < 0.01 vs the free AMB group
  3. aThe survival rate 25 days post infection (n = 20)