| |
Log CFU gram tissue (n = 3)
|
Survival ratioa (%, n = 20)
|
|---|
|
Lung
|
Spleen
|
Kidney
|
Liver
|
|---|
|
Control (untreated)
|
4.35 ± 0.27
|
3.08 ± 0.25
|
4.78 ± 0.33
|
3.41 ± 0.34
|
0.0
|
|
PBS
|
4.29 ± 0.35
|
3.14 ± 0.21
|
4.75 ± 0.29
|
3.34 ± 0.33
|
0.0
|
|
Free AMB
|
2.51 ± 0.11*
|
1.12 ± 0.09*
|
1.21 ± 0.26*
|
1.87 ± 0.25*
|
55.0
|
|
CDA-AMB-NPs
|
1.01 ± 0.06*#
|
Nil**
|
Nil**
|
Nil**
|
95.0
|
- Values are expressed as mean ± SEM from four separate experiments. t test values (two-tailed) are significant
- *p < 0.05, **p < 0.01 vs control; #p < 0.01 vs the free AMB group
-
aThe survival rate 25 days post infection (n = 20)
