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Table 4 The ratio of survived mice and CFU in different organs of infected mice

From: Enhanced Antifungal Activity by Ab-Modified Amphotericin B-Loaded Nanoparticles Using a pH-Responsive Block Copolymer

 

Log CFU gram tissue (n = 3)

Survival ratioa (%, n = 20)

Lung

Spleen

Kidney

Liver

Control (untreated)

4.35 ± 0.27

3.08 ± 0.25

4.78 ± 0.33

3.41 ± 0.34

0.0

PBS

4.29 ± 0.35

3.14 ± 0.21

4.75 ± 0.29

3.34 ± 0.33

0.0

Free AMB

2.51 ± 0.11*

1.12 ± 0.09*

1.21 ± 0.26*

1.87 ± 0.25*

55.0

CDA-AMB-NPs

1.01 ± 0.06*#

Nil**

Nil**

Nil**

95.0

  1. Values are expressed as mean ± SEM from four separate experiments. t test values (two-tailed) are significant
  2. *p < 0.05, **p < 0.01 vs control; #p < 0.01 vs the free AMB group
  3. aThe survival rate 25 days post infection (n = 20)

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