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Table 3 Mean biochemical parameters of blood serum from the control group and groups treated with diamond (DN), graphite (GN), and graphene oxide (GO) nanoparticles

From: Biodistribution of a High Dose of Diamond, Graphite, and Graphene Oxide Nanoparticles After Multiple Intraperitoneal Injections in Rats

  DN GN GO Control ANOVA
P value
AST (IU/L) 353.7 ± 165.45 403.4 ± 169.31 363.4 ± 174.53 273.0 ± 193.34 0.861
ALT (IU/L) 89.0 ± 37.46 102.2 ± 43.10 113.5 ± 72.89 123.3 ± 70.19 0.763
ALP (IU/L) 183.1a ± 42.44 285.1b ± 61.57 182.8a ± 25.74 175.5a ± 25.08 0.000
Glucose (mg/dL) 145.7 b ± 32.89 138.1b ± 19.78 144.4b ± 24.59 218.8a ± 56.77 0.003
Creatinine (mg/dL) 0.36a ± 0.205 0.29b ± 0.147 0.49a ± 0.098 0.54a ± 0.100 0.023
BUN (mg/dL) 49.4 ± 4.37 55.3 ± 10.16 50.9 ± 5.16 53.2 ± 11.29 0.634
TP (g/L) 57.2 ± 3.06 55.3 ± 3.33 55.3 ± 5.57 59.0 ± 5.22 0.440
Albumin (g/L) 48.5 ± 4.04 48.2 ± 3.60 49.8 ± 5.27 49.8 ± 5.19 0.882
LDH (U/L) 1496 ± 420.7 1468 ± 313.3 1516 ± 297.3 1209 ± 463.5 0.481
TG (mg/dL) 135.4 ± 34.97 99.6 ± 30.18 117.1 ± 24.63 103.4 ± 26.48 0.175
  1. The results are means of multiple determinations (n = 6) with ± standard deviation
  2. a,bValues with different superscripts are significantly different (P ≤ 0.05)
  3. AST aspartate aminotransferase, ALT alanine aminotransferase, ALP alkaline phosphatase, BUN blood urea nitrogen, TP total protein, LDH lactate dehydrogenase, TG triglycerides