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Table 1 Pharmacokinetic parameters of CUR fraction following single dose oral administration of CUR and CUR@PVP nanofiber in C57BL/6 mice (n = 24) at 25 mg/kg

From: Enhanced Bioavailability and Anticancer Effect of Curcumin-Loaded Electrospun Nanofiber: In Vitro and In Vivo Study

Parameter

CUR

CUR@PVP nanofiber

C max (ng/ml)

14 ± 3

167 ± 19***

T max (min)

120

60

AUC0−t (ng.min/ml)

2720 ± 124

31,238 ± 563***

  1. Values reported as mean ± SEM (n = 24). AUC area under the plasma concentration-time curve, C max peak concentration, T max time to reach peak concentration. ***P < 0.001

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