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Fig. 4 | Nanoscale Research Letters

Fig. 4

From: Tissue Plasminogen Activator Binding to Superparamagnetic Iron Oxide Nanoparticle—Covalent Versus Adsorptive Approach

Fig. 4

tPA activity of functionalized SPIONs with covalent and non-covalent tPA. a–c tPA activity of covalent and non-covalent functionalized SPIONs measured with the chromogenic S-2288 activity assay. a tPA activity measured after 24 h. b tPA activity measured after 40 days. c tPA activity calculated by the absorption change of p-nitroaniline emerging within the first 2 h during the kinetics shown in (a and b). d, e Activity measurement of covalent and non-covalent functionalized SPIONs after 24 h and 40 days, measured with thrombus-mimicking fibrin-containing agarose plates. f tPA activity calculated by the distance between the wall of the sample holes and the edge of the fibrinolysis zones of no-coated and coated SPIONs after 24 h and 40 days

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