Fig. 6
The secretion level of cytokines a IFN-γ, b IL-4, and c IL-2 in serum of BALB/c mice after immunization with HBc VLPs, CpG@HBc VLPs, CpG-Au@HBc VLPs, CpG-Au + HBc VLPs, CFA/IFA + HBc VLPs, and PBS, respectively. The data shown is a representative of the three independent experiments, and the statistical significance of the results was analyzed and indicated *p < 0.05; **p < 0.01. ns no significant difference