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Fig. 7 | Nanoscale Research Letters

Fig. 7

From: ICAM-1-Targeted Liposomes Loaded with Liver X Receptor Agonists Suppress PDGF-Induced Proliferation of Vascular Smooth Muscle Cells

Fig. 7

Anti-ICAM-1-T0901317 liposomes inhibit PDGF-BB-induced G1 → S phase progression by inhibiting Rb phosphorylation and MCM6 expression. Cells were pre-treated for 24 h with PDGF-BB (20 μg/mL) followed by treatment with targeted and nontargeted liposomes, T0901317, or control liposomes. a Cell cycle progression was assessed by flow cytometry. Anti-ICAM-1-T0901317 liposomes caused cells to remain in G1. b Cell cycle quantification is represented by the histogram. c Whole-cell proteins were assayed by western blotting. d Bar graphs showing the quantification of western blots. Data are expressed as a percentage of the control. Values were expressed as the means ± SD (n = 3). **P < 0.01

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