Account

Table 2 Parameter optimization by response surface methodology

From: Preparation of Glycyrrhetinic Acid Liposomes Using Lyophilization Monophase Solution Method: Preformulation, Optimization, and In Vitro Evaluation

No.	Factor^a			Dependent variables^b
No.	X ₁	X ₂	X ₃	MD (nm)	EE (%)
1	360	180	50	224.7	56.26
2	480	120	50	217.9	67.53
3	480	180	40	239.5	63.82
4	600	60	50	229.3	60.24
5	600	180	50	226.8	68.61
6	480	120	50	220.3	70.42
7	480	60	60	218.6	61.47
8	480	120	50	228.7	66.25
9	360	120	40	233.3	58.35
10	480	120	50	216.4	67.52
11	360	120	60	223.3	57.26
12	480	180	60	215.7	67.25
13	480	60	40	233.2	63.86
14	600	120	40	230.8	67.25
15	360	60	50	218.9	57.82
16	600	120	60	234.6	67.74
17	480	120	50	225.1	71.28

^aX₁ quantity of SPC, X₂ quantity of cholesterol, and X₃ volume percentage of TBA
^bMD mean diameter, EE entrapment efficiency

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