Preparation and Characterization of Tadpole- and Sphere-Shaped Hemin Nanoparticles for Enhanced Solubility

Table 1 Solubility of free hemin and hemin nanoparticles at different temperatures

Sample	Solubility (mg/mL)
Sample	25 °C	37 °C	60 °C	80 °C
Free hemin	0.009 ± 0.000c	0.060 ± 0.002c	0.144 ± 0.004c	0.235 ± 0.008c
Sphere-shaped nanoparticles	1.333 ± 0.023a	1.499 ± 0.072a	1.889 ± 0.081a	3.853 ± 0.124a
Tadpole-shaped nanoparticles	0.997 ± 0.045b	1.231 ± 0.035b	1.521 ± 0.058b	1.795 ± 0.050b

The values correspond to the mean ± standard deviation. Values within each column followed by different letters indicate significant differences (P < 0.05)