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Table 3 The percentages of rat glioma C6 cells for each level of genotoxicity after 6 h of treatment with the free form of compounds Les-3288 and Les-3833, and their complexes with the polymeric nanocarrier (PNC)

From: Enhanced Proapoptotic Effects of Water Dispersed Complexes of 4-Thiazolidinone-Based Chemotherapeutics with a PEG-Containing Polymeric Nanocarrier

Sample Comet class (% of cells) DI
0 1 2 3 4
Control 72.0 ± 0.5 28.0 ± 0.6     28.00 ± 0.58
Les-3288 25.3 ± 0.2 28.0 ± 0.6 37.3 ± 0.1 8.0 ± 0.3 1.3 ± 0.1 131.80 ± 0.74***
Les-3288 + PNC 62.6 ± 0.2 14.7 ± 0.9 10.7 ± 0.3 12.0 ± 0.6   72.10 ± 3.29***
Les-3833 12.0 ± 0.2 12.0 ± 0.6 41.4 ± 1.3 33.3 ± 0.2 1.3 ± 0.1 199.90 ± 2.35***
Les-3833 + PNC 10.6 ± 0.2 56.0 ± 0.3 16.0 ± 0.1 12.0 ± 0.1 5.3 ± 0.1 145.20 ± 0.85***
PNC 74.6 ± 0.9 25.3 ± 0.2     25.30 ± 0.17
Dox 12.0 ± 0.1 30.6 ± 0.4 25.3 ± 0.3 24.0 ± 0.2 8.0 ± 0.1 185.2 ± 0.23***
  1. Damage index (DI): ***P < 0.001 compared with untreated control cells