Oral Administration of Resveratrol-Loaded Solid Lipid Nanoparticle Improves Insulin Resistance Through Targeting Expression of SNARE Proteins in Adipose and Muscle Tissue in Rats with Type 2 Diabetes

Table 3 The effect of RES and SLN-RES treatment on the oxidant and antioxidant indicators in diabetic rat models

Groups	HC	DC	RES	SLN-RES
TAC (mM)	0.26 ± 0.04	0.12 ± 0.01	0.18 ± 0.03^α*	0.23 ± 0.01^α#πδ
-SH (mM)	0.38 ± 0.06	0.17 ± 0.04	0.20 ± 0.06	0.25 ± 0.08^α+
MDA (μM)	0.48 ± 0.12	1.24 ± 0.06	0.82 ± 0.12^α#	0.59 ± 0.03^α#π
TOS (μmol H₂O₂ equiv/l)	1.40 ± 0.13	1.95 ± 0.18	1.86 ± 0.15	1.59 ± 0.10^α#

HC healthy control, DC diabetic control, RES resveratrol treatment 10 mg/kg, SLN-RES resveratrol-loaded solid lipid nanoparticles containing 10 mg/kg of resveratrol, TAC total antioxidant capacity, -SH total thiol group, MDA malondialdehyde, TOS total oxidant status. Data were expressed as mean ± SD
^αCompared to the DC group
^δThere was a significant difference between RES and SLN-RES group (p < 0.05)
^πRestored to the HC group (there was no significant difference compared to the HC group (p > 0.05)).
*p < 0.05
+p < 0.01
#p < 0.001