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Nanoscale Research Letters

Table 3 The effect of RES and SLN-RES treatment on the oxidant and antioxidant indicators in diabetic rat models

From: Oral Administration of Resveratrol-Loaded Solid Lipid Nanoparticle Improves Insulin Resistance Through Targeting Expression of SNARE Proteins in Adipose and Muscle Tissue in Rats with Type 2 Diabetes

Groups HC DC RES SLN-RES
TAC (mM) 0.26 ± 0.04 0.12 ± 0.01 0.18 ± 0.03α* 0.23 ± 0.01α#πδ
-SH (mM) 0.38 ± 0.06 0.17 ± 0.04 0.20 ± 0.06 0.25 ± 0.08α+
MDA (μM) 0.48 ± 0.12 1.24 ± 0.06 0.82 ± 0.12α# 0.59 ± 0.03α#π
TOS (μmol H2O2 equiv/l) 1.40 ± 0.13 1.95 ± 0.18 1.86 ± 0.15 1.59 ± 0.10α#
  1. HC healthy control, DC diabetic control, RES resveratrol treatment 10 mg/kg, SLN-RES resveratrol-loaded solid lipid nanoparticles containing 10 mg/kg of resveratrol, TAC total antioxidant capacity, -SH total thiol group, MDA malondialdehyde, TOS total oxidant status. Data were expressed as mean ± SD
  2. αCompared to the DC group
  3. δThere was a significant difference between RES and SLN-RES group (p < 0.05)
  4. πRestored to the HC group (there was no significant difference compared to the HC group (p > 0.05)).
  5. *p < 0.05
  6. +p < 0.01
  7. #p < 0.001
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