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Fig. 5 | Nanoscale Research Letters

Fig. 5

From: Ferumoxytol Attenuates the Function of MDSCs to Ameliorate LPS-Induced Immunosuppression in Sepsis

Fig. 5

FMT ameliorates liver injury in LPS-induced septic mice. a Mice received either PBS or an i.p. injection of 5 mg/kg body weight of bacterial LPS on day 0. After 1 h and 5 days, FMT at a dose of 10 mg/kg or 100 μL saline was administered via tail vein. Mice were divided into four groups (n = 6): control, receiving vehicle; LPS, receiving LPS only; FMT, receiving FMT only; and LPS + FMT, receiving LPS and FMT. b Lung and liver tissues were stained with hematoxylin and eosin. c-d Serum transaminases (ALT and AST) were measured (n = 6). Cytokine levels (TNF-a, IL-1β and MCP-1) were measured by ELISA. e-g Effects of LPS-induced sepsis on cytokine production in vehicle or ferumoxytol-treated mice. Cytokine levels measured by ELISA in the serum of vehicle or ferumoxytol-treated mice following i.p. LPS challenge (50 mg/kg). **p < 0.01 as determined by an unpaired Student’s t test

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