Fig. 1

Structure of dacarbazine (DBZ) and all-trans retinoic acid (ATRA). Schematic illustration of DBZ/ATRA-loaded lipid nanoformulations is presented. The lipid nanoformulation was prepared by ultrasonication method. Both the DBZ and ATRA are hydrophobic molecules with a molecular weight of less than 300 g/mol. The hydrophobic molecules are expected to concentrate in the core of the nanoparticles stabilized by a surfactant