Fig. 4

Inhibition of either HDAC1 or miR-124-5p suppresses oxidative stress and inflammation in depressed rats. a–c Effect of inhibition of either HDAC1 or miR-124-5p on SOD, MDA and GSH concentration in serum of depressed rats; d–f Effect of inhibition of either HDAC1 or miR-124-5p on IL-1β, TNF-α, and NO concentration in serum of depressed rats; n = 10; a P < 0.05 compared with the normal group; b P < 0.05 compared with the sh-NC group; c P < 0.05 compared with the anti-miR-NC group. Comparisons among multiple groups were evaluated by one-way ANOVA, and pairwise comparisons by Tukey’s post hoc test