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Fig. 4 | Nanoscale Research Letters

Fig. 4

From: Potential Osteoinductive Effects of Hydroxyapatite Nanoparticles on Mesenchymal Stem Cells by Endothelial Cell Interaction

Fig. 4

Indirect effects of HAPs on the expression of osteogenic differentiation-related genes. a RUNX-2, b Col I, c OCN, d ALP, e NANOG, f OCT3/4, and g SOX2 gene levels in hWJ-MSCs cultured with CM for the indicated time. *P < 0.05; **P < 0.01; ***P < 0.001 versus control group; &P < 0.05; &&P < 0.01; &&&P < 0.001 versus the m-HAP group; #P < 0.05; ##P < 0.01 versus the np20 group. Cells incubated in osteogenic medium without HAPs treatment were used as the control group. Abbreviations: HAPs hydroxyapatite particles, m-HAP micro-sized HAP particles, hWJ-MSCs human umbilical cord Wharton’s jelly-derived mesenchymal stem cells, RUNX-2 runt-related transcription factor 2, Col I type I collagen, OCN osteocalcin, ALP alkaline phosphatase, SOX 2 SRY-related HMG-box 2

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