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Fig. 4 | Nanoscale Research Letters

Fig. 4

From: Tuning the Toxicity of Reactive Oxygen Species into Advanced Tumor Therapy

Fig. 4

a Schematic working mechanisms of photothermal and photodynamic therapy effects exerted by Au NRs at low light doses. b Schematic diagrams of the working model of R-AIE-Au for fluorescence and CT imaging-guided X-ray-induced enhanced RT and PDT. c Schematic illustration of the cancer therapy mechanism of AuNC@DHLA PDT. AuNC@DHLA can be internalized via caveolae-mediated endocytosis and accumulate in lysosomes, where the generation of ROS leads to LMP. Subsequent altered MMP, mitochondrial morphology, and cytoskeleton destruction finally lead to cell death. The in vivo PDT was achieved with NIR fs laser irradiation [34,35,36]

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