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Fig. 13 | Nanoscale Research Letters

Fig. 13

From: Photodynamic Therapeutic Effect of Nanostructured Metal Sulfide Photosensitizers on Cancer Treatment

Fig. 13

a Schematics illustrating the in vivo therapeutic process using a Bi2S3 nanorod-P(NIPAM-co-AM)-zinc protoporphyrin IX-Pep (BPZP) system through suppressing HO-1 activity and promoting NIR laser-irradiated ROS production after intravenous administration. b, c Viability of cells treated with various concentrations of ZP, BPP, BPP + ZP, and BPZP for 24 h with or without 808 nm laser irradiation (0.75 W cm−2, 10 min). d Representative photos of tumors dissected at 14 d post-treatment. e Tumor growth curves of mice IV injected with ZP, BPP, BPP + ZP, and BPZP (equivalent to 20 mg kg−1 Bi2S3 or 0.224 mg kg−1 ZP) with 808 nm laser irradiation (0.75 W cm−2, 5 min) for 14 d. Reproduced with permission from Ref. [92]. Copyright 2019, WILEY–VCH Verlag GmbH & Co. KGaA, Weinheim, Germany

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